Methods to evaluate the impact of SARS-CoV-2 nucleocapsid mutations on antigen detection by rapid diagnostic tests.

doi:10.2144/btn-2022-0020

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Article

Methods to evaluate the impact of SARS-CoV-2 nucleocapsid mutations on antigen detection by rapid diagnostic tests.

BioTechniques - 1 Sept 2022

Tieman Bryan C, Kovacs Stephen, Rodgers Mary A, Mohaimani Aurash, Gregory Svetoslava, Christensen David, Moore Jeffrey A, Schurig-Briccio Lici, Hartnett James, Kar Alak, Leeman Aaron, Palmer Angel, Rogers Lauren, Dragoo Brian, Muszynski Steven, Noblesmith Deborah, Gardner Samantha, Snipe-Bushey Abigail, Kill Anna, Luo Xinxin, Cherukuri Sneha, Rae Tracey, Marohnic Christopher C, Cloherty Gavin A, Muerhoff Anthony Scott, Hemken Philip M

Abstract excerpt

Mutations in the nucleocapsid of SARS-CoV-2 may interfere with antigen detection by diagnostic tests. We used several methods to evaluate the effect of various SARS-CoV-2 nucleocapsid mutations on the performance of the Panbio™ and BinaxNOW™ lateral flow rapid antigen tests and a prototype high-throughput immunoassay that utilizes Panbio antibodies. Variant detection was also evaluated by immunoblot and BIAcore™...

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Identifiers

PMID: 36004516
DOI: 10.2144/btn-2022-0020
PMCID: PMC9407365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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