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Considering epitopes conservity in targeting SARS-CoV-2 mutations in variants: a novel immunoinformatics approach to vaccine design.

Scientific reports - 18 Aug 2022

Bagherzadeh Mohammad Aref, Izadi Mohammad, Baesi Kazem, Jahromi Mirza Ali Mofazzal, Pirestani Majid

Abstract excerpt

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has gained mutations at an alarming rate in the past years. Developing mutations can increase the virus's pathogenicity and virulence; reduce the efficacy of vaccines, antibodies neutralization, and even challenge adaptive immunity. So, it is essential to identify conserved epitopes (with fewer mutations) in different variants with appropriate...

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Identifiers

PMID: 35982065
DOI: 10.1038/s41598-022-18152-5
PMCID: PMC9386201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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