Article
In Situ Observation of Lysosomal Hypobromous Acid Fluctuations in the Brain of Mice with Depression Phenotypes by Two-Photon Fluorescence Imaging.
Analytical chemistry - 30 Aug 2022
Zhu Hanchuang, Jia Pan, Wang Xin, Tian Ying, Liu Caiyun, Li Xiwei, Wang Kun, Li Ping, Zhu Baocun, Tang Bo
Abstract excerpt
Excessive oxidative stress is the main cause of neurotransmitter metabolism disorder in the brain with depression. Lysosomal hypobromic acid (HOBr) is an important reactive oxygen species produced in oxidative stress. Its abnormal content can lead to macromolecular damage and neurodegenerative diseases. However, due to the high reactivity and low concentration of HOBr and the lack of in situ imaging methods, the...
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