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In Silico Analysis of the Effects of Omicron Spike Amino Acid Changes on the Interactions with Human Proteins.

Molecules (Basel, Switzerland) - 28 Jul 2022

D'Arminio Nancy, Giordano Deborah, Scafuri Bernardina, Biancaniello Carmen, Petrillo Mauro, Facchiano Angelo, Marabotti Anna

Abstract excerpt

The SARS-CoV-2 variant Omicron is characterized, among others, by more than 30 amino acid changes occurring on the spike glycoprotein with respect to the original SARS-CoV-2 spike protein. We report a comprehensive analysis of the effects of the Omicron spike amino acid changes in the interaction with human antibodies, obtained by modeling them into selected publicly available resolved 3D structures of...

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Identifiers

PMID: 35956778
DOI: 10.3390/molecules27154827
PMCID: PMC9370001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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