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Article

The role of macrophages phenotypes in the activation of resolution pathways within human granulosa cells.

Reproductive biology and endocrinology : RB&E - 10 Aug 2022

Martins Thaise S, Fonseca Bruno M, Rebelo Irene

Abstract excerpt

BACKGROUND: Inflammatory state within the ovaries can disrupt normal follicular dynamics, leading to reduced oocyte quality and infertility. How the production of inflammatory mediators generated by macrophages with different gene expression profile (M1 and M2) might activate inflammatory pathways, such as cyclooxygenase-2 (COX-2) and 5-, 12-, and 15-lipoxygenase (LOX), in human granulosa cells (hGCs) remains...

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Identifiers

PMID: 35948935
DOI: 10.1186/s12958-022-00983-6
PMCID: PMC9364504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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