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Increased CD163+ Macrophage Activation and High Expression of CD163 Promote Granulosa Cell Apoptosis in Polycystic Ovary Syndrome

1 Jul 2025

Abstract excerpt

Background: The inflammatory microenvironment disrupts the ovarian niche, impairing granulosa cell function and leading to aberrant follicular development, a key pathological feature of polycystic ovary syndrome (PCOS). However, the precise mechanisms by which inflammation influences granulosa cell function remain poorly understood. Methods: Differentially expressed genes (DEGs) were identified from the GSE34526...

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PMID: 40761381
DOI: 10.2147/jir.s532920

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