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Article

Fibroblast testing can inform medical management in individuals with mosaic variants detected on hereditary cancer panels.

Cancer genetics - 1 Aug 2022

Sutcliffe Erin G, Mester Jessica L, Susswein Lisa R, Roberts Maegan E, Marshall Megan L, Hruska Kathleen S

Abstract excerpt

Mosaic variants are regularly detected on hereditary cancer genetic tests. While some of these variants may be constitutional, the majority are likely limited to blood lineages. In the present study, we correlate clinical histories from individuals with mosaic findings identified on hereditary cancer testing and the outcomes of follow-up fibroblast (FB) testing. We observed 620 mosaic variants, including 339...

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PMID: 35926323
DOI: 10.1016/j.cancergen.2022.07.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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