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Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection

1 Aug 2022

Abstract excerpt

Members of the Klebsiella pneumoniae species complex frequently colonize the gut and colonization is associated with subsequent infection. To identify genes associated with progression from colonization to infection, we undertook a case-control comparative genomics study. Concordant cases (N = 85), where colonizing and invasive isolates were identical strain types, were matched to asymptomatically colonizing...

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PMID: 35915063
DOI: 10.1038/s41467-022-31990-1

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