Article
Genomic and epigenomic profiles distinguish pulmonary enteric adenocarcinoma from lung metastatic colorectal cancer.
EBioMedicine - 1 Aug 2022
Zuo Ying, Zhong Jia, Bai Hua, Xu Bin, Wang Zhijie, Li Weihua, Chen Yedan, Jin Shi, Wang Shuhang, Wang Xin, Wan Rui, Xu Jiachen, Fei Kailun, Han Jiefei, Yang Zhenlin, Bao Hua, Shao Yang, Ying Jianming, Song Qibin, Duan Jianchun, Wang Jie
Abstract excerpt
BACKGROUND: As a rare subtype of lung adenocarcinoma, the diagnosis of pulmonary enteric adenocarcinoma (PEAC) remains challenging due to overlapping morphologic spectrum with lung metastatic colorectal cancer (lmCRC). However, the molecular features of PEAC as a separate lung cancer entity are poorly understood. METHODS: We performed whole-exome sequencing and targeted bisulfite sequencing of 32 PEAC and 30...
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