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Mechanisms of high-level fosfomycin resistance in Staphylococcus aureus epidemic lineage ST5

15 Jul 2022

Abstract excerpt

OBJECTIVES: Fosfomycin resistance has become a clinical concern. In this study, we analysed the dynamic change of fosfomycin MIC in the epidemic Staphylococcus aureus lineages in a teaching hospital in Shanghai for 12 years and sought to elucidate the major underlying mechanisms. METHODS: MLST was conducted for 4580 S. aureus isolates recovered from 2008 to 2019. Fosfomycin MIC was determined by the agar dilution...

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PMID: 35848785
DOI: 10.1093/jac/dkac236

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