Article
Clinical impact of TERT somatic mutation in telomerase-related gene mutation carriers after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Sept 2022
Ba Ibrahima, Kannengiesser Caroline, Mal Hervé, Reynaud-Gaubert Martine, Cottin Vincent, Hirschi Sandrine, Picard Clément, Borie Raphael
Abstract excerpt
Almost 25% of patients with pulmonary fibrosis referred for lung transplantation have a germline rare variant of a telomere-related gene. Acquired TERT promoter mutations may counterbalanced the germline defect and reduce the risk of hematological complications in this population. In a series of 34 patients with a germline telomere-related gene mutation who underwent lung transplantation, 12 (35%) patients had at...
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