Article
A knowledge graph approach to predict and interpret disease-causing gene interactions.
BMC bioinformatics - 29 Aug 2023
Renaux Alexandre, Terwagne Chloé, Cochez Michael, Tiddi Ilaria, Nowé Ann, Lenaerts Tom
Abstract excerpt
BACKGROUND: Understanding the impact of gene interactions on disease phenotypes is increasingly recognised as a crucial aspect of genetic disease research. This trend is reflected by the growing amount of clinical research on oligogenic diseases, where disease manifestations are influenced by combinations of variants on a few specific genes. Although statistical machine-learning methods have been developed to...
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