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Epochal coevolution of minor capsid protein in norovirus GII.4 variants with major capsid protein based on their interactions over the last five decades.

Virus research - 2 Oct 2022

Hong Xiaojing, Xue Liang, Gao Junshan, Jiang Yueting, Kou Xiaoxia

Abstract excerpt

Norovirus is a leading cause of viral gastroenteritis outbreaks worldwide, with GII.4 responsible for the majority of infections. Minor capsid protein VP2 has been found to have functions such as stabilizing virus particles, and VP2 is one of the highly variable proteins of norovirus, similar to major capsid protein VP1. However, whether the variation of VP2 is functionally driven still remains unclear. In this...

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PMID: 35817094
DOI: 10.1016/j.virusres.2022.198860

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