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A comprehensive analysis of prognosis prediction models based on pathway‑level, gene‑level and clinical information for glioblastoma

11 Jul 2018

Abstract excerpt

The present study aimed to develop a pathway‑based prognosis prediction model for glioblastoma (GBM). Univariate and multivariate Cox regression analysis were used to identify prognosis‑related genes and clinical factors using mRNA‑seq data of GBM samples from The Cancer Genome Atlas (TCGA) database. The expression matrix of prognosis‑related genes was transformed into pathway deregulation score (PDS) based on...

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PMID: 30015853
DOI: 10.3892/ijmm.2018.3765

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