Article
KIT-Associated Familial GIST Syndrome: Response to Tyrosine Kinase Inhibitors and Implications for Risk Management.
The oncologist - 5 Aug 2022
Brodey Alexandra, Kounnis Valentinos, Hawkes Lara, Jones Robin L, McVeigh Terri P, Cojocaru Elena
Abstract excerpt
Sporadic gastrointestinal stromal tumors (GIST) are rare tumors, with a median age at diagnosis of 60 years. Familial GISTs are very rare and typically associated with earlier onset, with an average age at diagnosis of 48 years. To date, just over 50 familial cases associated with a germline variant KIT or PDGFRa genes have been published. Therefore, there are many challenges in managing these patients, including...
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