Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gastrointestinal stromal tumors caused by novel germline variants in SDHB and KIT: a report of two cases and literature review.

Clinical journal of gastroenterology - 1 Oct 2022

Rasmussen Sean, Stueck Ashley, Colwell Bruce, Gaston Daniel, Carter Michael

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are usually caused by somatic mutations, but there are rare germline variants that predispose patients to the development of one or, more commonly, multiple GISTs. We present 2 cases of multifocal GISTs related to previously unreported germline variants. The first case is a 28-year-old female who developed multiple gastric GISTs with widespread abdominal metastases that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gastrointestinal Stromal Tumors
Share to Germ Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Imatinib Mesylate

Share to Mutation

Share to Proto-Oncogene Proteins c-kit

Share to Stomach Neoplasms

Share to Succinate Dehydrogenase

Source

Identifiers

PMID: 35821557
DOI: 10.1007/s12328-022-01672-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gastrointestinal stromal tumors caused by novel germline variants in SDHB and KIT: a report of two cases and literature review.PMID 35821557Read ↗

Update on Molecular Genetics of Gastrointestinal Stromal TumorsSemantic proximity Read ↗

Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics.Semantic proximity Read ↗

Gastrointestinal stromal tumors in children and young adults: a clinicopathologic and molecular genetic study of 22 Korean cases.Semantic proximity Read ↗

Gastrointestinal stromal tumors in the setting of multiple tumor syndromes.Semantic proximity Read ↗

SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors.Semantic proximity Read ↗

Inherited gastrointestinal stromal tumor syndromes: mutations, clinical features, and therapeutic implicationsSemantic proximity Read ↗

Utility of Clinical Next Generation Sequencing Tests in KIT/PDGFRA/SDH Wild-Type Gastrointestinal Stromal TumorsSemantic proximity Read ↗

[Hereditary and non-hereditary syndromic gastointestinal stromal tumours].Semantic proximity Read ↗

Expanded genetic testing of GIST patients identifies high proportion of non-syndromic patients with germline alterationsSemantic proximity Read ↗

Surgical Management of Germline Gastrointestinal Stromal Tumor.Semantic proximity Read ↗

Diagnosis, Treatment, and Prognosis of Patients with Primary Familial Gastrointestinal Stromal Tumor: A Case Report and Literature Review.Semantic proximity Read ↗

Multiple gastrointestinal stromal tumors with a germline c‐kit mutationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.