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Population-level Metagenomics Uncovers Distinct Effects of Multiple Medications on the Human Gut Microbiome

1 Jul 2022

Abstract excerpt

BACKGROUND & AIMS: Medication is a major determinant of human gut microbiome structure, and its overuse increases the risks of morbidity and mortality. However, effects of certain commonly prescribed drugs and multiple medications on the gut microbiome are still underinvestigated. METHODS: We performed shotgun metagenomic analysis of fecal samples from 4198 individuals in the Japanese 4D (Disease, Drug, Diet,...

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PMID: 35788347
DOI: 10.1053/j.gastro.2022.06.070

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