Article
Natural mutation in the regulatory gene (srrG) influences virulence-associated genes and enhances invasiveness in Streptococcus dysgalactiae subsp. equisimilis strains isolated from cases of streptococcal toxic shock syndrome.
EBioMedicine - 1 Jul 2022
Ikebe Tadayoshi, Otsuka Hitoshi, Chiba Kazuki, Kazawa Yu, Yamaguchi Takahiro, Okuno Rumi, Date Yoshimi, Sasaki Mari, Isobe Junko, Ohnishi Makoto, Akeda Yukihiro
Abstract excerpt
BACKGROUND: Streptococcus dysgalactiae subspecies equisimilis (SDSE) has emerged as an important cause of severe invasive infections including streptococcal toxic shock syndrome (STSS). The present study aimed to identify genes involved in differences in invasiveness between STSS and non-invasive SDSE isolates. METHODS: STSS and non-invasive SDSE isolates were analysed to identify csrS/csrR mutations, followed by...
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