Article
Solution Structural Studies of Pre-amyloid Oligomer States of the Biofilm Protein Aap.
Journal of molecular biology - 30 Aug 2022
Yarawsky Alexander E, Hopkins Jesse B, Chatzimagas Leonie, Hub Jochen S, Herr Andrew B
Abstract excerpt
Staphylococcus epidermidis is a commensal bacterium on human skin that is also the leading cause of medical device-related infections. The accumulation-associated protein (Aap) from S. epidermidis is a critical factor for infection via its ability to mediate biofilm formation. The B-repeat superdomain of Aap is composed of 5 to 17 Zn2+-binding B-repeats, which undergo rapid, reversible assembly to form dimer and...
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