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Article

Pre-operative exercise and pyrexia as modifying factors in malignant hyperthermia (MH).

Neuromuscular disorders : NMD - 1 Aug 2022

Riazi Sheila, Bersselaar Luuk R van den, Islander Gunilla, Heytens Luc, Snoeck Marc M J, Bjorksten Andrew, Gillies Robyn, Dranitsaris George, Hellblom Anna, Treves Susan, Kunst Gudrun, Voermans Nicol C, Jungbluth Heinz

Abstract excerpt

Malignant hyperthermia (MH) is a life-threatening reaction triggered by volatile anesthetics and succinylcholine. MH is caused by mutations in the skeletal muscle ryanodine receptor (RYR1) gene, as is rhabdomyolysis triggered by exertion and/or pyrexia. The discrepancy between the prevalence of risk genotypes and actual MH incidence remains unexplained. We investigated the role of pre-operative exercise and...

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Identifiers

PMID: 35738978
DOI: 10.1016/j.nmd.2022.06.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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