Article
A Japanese case of castration-resistant prostate cancer with BRCA2 and RB1 co-loss and TP53 mutation: a case report.
BMC medical genomics - 20 Jun 2022
Iwasawa Tomohiro, Kosaka Takeo, Morita Shinya, Mikami Shuji, Nakamura Kohei, Hongo Hiroshi, Nishihara Hiroshi, Oya Mototsugu
Abstract excerpt
BACKGROUND: Abnormalities in homologous recombination contribute to the aggressive nature of castration-resistant prostate cancer. Retinoblastoma transcriptional corepressor 1 (RB1) and breast cancer 2 (BRCA2) exist close to each other in the same chromosome, and the significance of their concurrent loss has become a hot topic in the field of cancer research. CASE PRESENTATION: A 61-year-old man presented with a...
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