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Article

Mast cell leukemia with novel BRAF variant and concomitant atypical KIT variant.

Cancer genetics - 1 Aug 2022

Chen Tiane, Malysz Jozef, Washburn Erik, Songdej Natthapol, Zhang Yong, Bayerl Michael

Abstract excerpt

Mast cell leukemia (MCL) is a leukemic variant of systemic mastocytosis defined by mast cells ≥ 20% of marrow nucleated cells. Its incidence is < 1% of all systemic mastocytosis cases [1]. Clinical characteristics and treatment of the disease are not well established and overall prognosis is very poor. We report a case of de novo mast cell leukemia with novel BRAF variant, concomitant KIT exon 9 missense mutation...

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Identifiers

PMID: 35717863
DOI: 10.1016/j.cancergen.2022.05.040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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