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Synergistic interactions of repurposed drugs that inhibit Nsp1, a major virulence factor for COVID-19

17 Jun 2022

Abstract excerpt

Nsp1 is one of the first proteins expressed from the SARS-CoV-2 genome and is a major virulence factor for COVID-19. A rapid multiplexed assay for detecting the action of Nsp1 was developed in cultured lung cells. The assay is based on the acute cytopathic effects induced by Nsp1. Virtual screening was used to stratify compounds that interact with two functional Nsp1 sites: the RNA-binding groove and C-terminal...

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PMID: 35715434
DOI: 10.1038/s41598-022-14194-x

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