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The downregulation of miR ‐22 and miR ‐372 may contribute to gestational diabetes mellitus through regulating glucose metabolism via the PI3K / AKT / GLUT4 pathway

17 Jun 2022

Abstract excerpt

BACKGROUND: Identifying effective regulatory mechanisms will be significant for Gestational diabetes mellitus (GDM) diagnosis and treatment. METHODS: The expressions of miR-22 and miR-372 in placenta tissues from 75 pregnant women with GDM and 75 matched healthy controls and HRT8/SVneo cells (a model of insulin resistance) were analyzed by qPCR. The expressions of PI3K, AKT, IRS, and GLUT4 in high glucose-treated...

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PMID: 35712865
DOI: 10.1002/jcla.24557

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