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circMAP3K4 regulates insulin resistance in trophoblast cells during gestational diabetes mellitus by modulating the miR-6795-5p/PTPN1 axis

21 Apr 2022

Abstract excerpt

BACKGROUND: Insulin resistance (IR) during gestational diabetes mellitus (GDM) has been linked to dysregulated insulin-PI3K/Akt pathway. A defective insulin-PI3K/Akt pathway and dysregulated circular RNA (circRNA) levels have been observed in the placentas of patients with GDM; however, the mechanisms underlying this association remain unclear. METHODS: circRNAs potentially associated with GDM were selected...

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PMID: 35449053
DOI: 10.1186/s12967-022-03386-8

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