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Clinical Utility and Outcomes Impact of Crystal Digital PCR of Sensitizing and Resistance EGFR Mutations in Patients With Advanced Non-Small Cell Lung Cancer.

Clinical lung cancer - 1 Sept 2022

Riudavets Mariona, Lamberts Virginie, Vasseur Damien, Auclin Edouard, Aldea Mihaela, Jovelet Cécile, Naltet Charles, Lavaud Pernelle, Gazzah Anas, Aboubakar Frank, Dorta Miriam, Remon Jordi, Rouleau Etienne, Ngocamus Maud, Nicotra Claudio, Lacroix Ludovic, Besse Benjamin, Mezquita Laura, Planchard David

Abstract excerpt

BACKGROUND: EGFRm represent 15% of advanced NSCLC in European patients. LB for molecular profiling offers a non-invasive alternative to tissue. cdPCR is a high-sensitive and low-cost LB to detect molecular alterations. We aimed to describe cdPCR clinical utility for EGFRm detection in advanced NSCLC. METHODS: Prospective blood sample collection in patients with advanced NSCLC harbouring EGFRm either at diagnosis,...

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PMID: 35660356
DOI: 10.1016/j.cllc.2022.05.010

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