Using generative adversarial networks for genome variant calling from low depth ONT sequencing data.

Abstract excerpt

Genome variant calling is a challenging yet critical task for subsequent studies. Existing methods almost rely on high depth DNA sequencing data. Performance on low depth data drops a lot. Using public Oxford Nanopore (ONT) data of human being from the Genome in a Bottle (GIAB) Consortium, we trained a generative adversarial network for low depth variant calling. Our method, noted as LDV-Caller, can project high...

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