Article
Differential characteristics of TP53 alterations in pure erythroid leukemia arising after exposure to cytotoxic therapy.
Leukemia research - 1 Jul 2022
Tashakori Mehrnoosh, Wang Wei, Kadia Tapan M, Daver Naval G, Montalban-Bravo Guillermo, Loghavi Sanam, Wang Sa A, Medeiros L Jeffrey, Ravandi Farhad, Khoury Joseph D
Abstract excerpt
Pure erythroid leukemia (PEL) is a rare acute leukemia with a dismal prognosis. TP53 mutations are a dominant feature of PEL, but the characteristics of TP53 alterations in PEL without prior exposure to cytotoxic therapy (d-PEL) or with such exposure (t-PEL) is unknown. We studied 25 patients with TP53-mutated PEL including 16 d-PEL and 9 t-PEL. Both groups had comparable clinical findings and overall survival....
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