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Article

Current state of CFTR modulators for treatment of Cystic Fibrosis.

Current opinion in pharmacology - 1 Aug 2022

Despotes Katherine A, Donaldson Scott H

Abstract excerpt

Small molecular modulators of the cystic fibrosis transmembrane conductance regulator protein are transforming the care of people with cystic fibrosis. Highly effective modulators are now approved for nearly 90% of the adult CF population. They dramatically improve lung function, respiratory symptoms, and reduce pulmonary exacerbations. Recent efforts are expanding the availability of these therapies to a growing...

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PMID: 35609385
DOI: 10.1016/j.coph.2022.102239

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