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Article

Genetically engineered animal models for Marfan syndrome: challenges associated with the generation of pig models for diseases caused by haploinsufficiency.

The Journal of reproduction and development - 1 Aug 2022

Jack Naomi, Muto Tomoyuki, Iemitsu Keigo, Watanabe Tamaki, Umeyama Kazuhiro, Ohgane Jun, Nagashima Hiroshi

Abstract excerpt

Recent developments in reproductive biology have enabled the generation of genetically engineered pigs as models for inherited human diseases. Although a variety of such models for monogenic diseases are currently available, reproduction of human diseases caused by haploinsufficiency remains a major challenge. The present study compares the phenotypes of mouse and pig models of Marfan syndrome (MFS), with a...

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Identifiers

PMID: 35598970
DOI: 10.1262/jrd.2022-027
PMCID: PMC9334321

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