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Article

Characterization of m6A modifications in the contemporary Zika virus genome and host cellular transcripts

19 May 2022

Abstract excerpt

Abstract Zika virus (ZIKV) suddenly evolved from a neglected arthropod‐borne flavivirus into a pandemic pathogen during 2015–2016. A panel of amino acid mutations has been shown to be responsible for the enhanced neurovirulence and transmissibility of ZIKV. Recent studies have demonstrated that ZIKV genomic RNA is modified by host N6‐methyladenosine (m6A) machinery during viral replication in host cells, and the...

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PMID: 35587571
DOI: 10.1002/jmv.27869

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