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Article

Mechanism of resistance to immune checkpoint inhibitors

1 Jan 2019

Abstract excerpt

Immune checkpoint inhibitors (ICI) have revolutionized the management of cancer over the last decade. Instead of targeting the cancer cell directly these agents work by augmenting the immune response towards tumor. Although they are associated with improved responses compared to traditional treatments in several malignancies, a majority of the patients don't respond to ICIs even when used in the frontline...

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PMID: 35582715
DOI: 10.20517/cdr.2018.015

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