Article
Novel hypercapsulation RNA thermosensor variants in Neisseria meningitidis and their association with invasive meningococcal disease: a genetic and phenotypic investigation and molecular epidemiological study.
The Lancet. Microbe - 1 Dec 2020
Karlsson Jens, Eichner Hannes, Andersson Cecilia, Jacobsson Susanne, Loh Edmund
Abstract excerpt
BACKGROUND: Neisseria meningitidis is the causative agent of invasive meningococcal disease and the polysaccharide capsule is one of its major virulence factors. Biosynthesis of the meningococcal capsule is controlled by an RNA thermosensor (RNAT) in the 5'-untranslated region (5'-UTR) of the cssA gene. The function of the RNAT depends on an 8-bp tandem repeat configuration. We aimed to identify and characterise...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.