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Article

Developing a novel DNA methylation risk score for survival and identification of prognostic gene mutations in endometrial cancer: a study based on TCGA data.

Japanese journal of clinical oncology - 18 Sept 2022

Shen Po-Chien, Wang Ying-Fu, Chang Hao-Chih, Huang Wen-Yen, Lo Cheng-Hsiang, Su Yu-Fu, Yang Jen-Fu, Lin Chun-Shu, Dai Yang-Hong

Abstract excerpt

BACKGROUND: Few studies have focused on DNA methylation in endometrial cancer. The aim of our study is identify its role in endometrial cancer prognosis. METHODS: A publicly available dataset was retrieved from The Cancer Genome Atlas. For validation of expression alteration due to methylation, RNA sequencing data were obtained from other independent cohorts. MethSurv was used to search for candidate CpG probes,...

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PMID: 35532291
DOI: 10.1093/jjco/hyac077

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