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Case Report: Giant Paraganglioma of the Skull Base With Two Somatic Mutations in SDHB and PTEN Genes.

Frontiers in endocrinology - 1 Jan 2022

Main Ailsa Maria, Benndorf Götz, Feldt-Rasmussen Ulla, Fugleholm Kåre, Kistorp Thomas, Loya Anand C, Poulsgaard Lars, Rasmussen Åse Krogh, Rossing Maria, Sølling Christine, Klose Marianne Christina

Abstract excerpt

Head and neck paragangliomas (HNPGLs) are neuroendocrine tumors. They arise from the parasympathetic ganglia and can be either sporadic or due to hereditary syndromes (up to 40%). Most HNPGLs do not produce significant amounts of catecholamines. We report a case of a giant paraganglioma of the skull base with an unusually severe presentation secondary to excessive release of norepinephrine, with a good outcome...

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Identifiers

PMID: 35498434
DOI: 10.3389/fendo.2022.857504
PMCID: PMC9044027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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