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Article

A novel ND1 mitochondrial DNA mutation is maternally inherited in growth hormone transgenesis in amago salmon (Oncorhynchus masou ishikawae).

Scientific reports - 25 Apr 2022

Sato Tomohiko, Goto-Inoue Naoko, Kimishima Masaya, Toyoharu Jike, Minei Ryuhei, Ogura Atsushi, Nagoya Hiroyuki, Mori Tsukasa

Abstract excerpt

Growth hormone (GH) transgenesis can be used to manipulate the growth performance of fish and mammals. In this study, homozygous and hemizygous GH-transgenic amago salmon (Oncorhynchus masou ishikawae) derived from a single female exhibited hypoglycemia. Proteomic and signal network analyses using iTRAQ indicated a decreased NAD+/NADH ratio in transgenic fish, indicative of reduced mitochondrial ND1 function and...

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Identifiers

PMID: 35469048
DOI: 10.1038/s41598-022-10521-4
PMCID: PMC9038734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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