Article
Transcriptional and post-transcriptional regulation of checkpoint genes on the tumour side of the immunological synapse.
Heredity - 1 Jul 2022
Dobosz Paula, Stempor Przemysław A, Ramírez Moreno Miguel, Bulgakova Natalia A
Abstract excerpt
Cancer is a disease of the genome, therefore, its development has a clear Mendelian component, demonstrated by well-studied genes such as BRCA1 and BRCA2 in breast cancer risk. However, it is known that a single genetic variant is not enough for cancer to develop leading to the theory of multistage carcinogenesis. In many cases, it is a sequence of events, acquired somatic mutations, or simply polygenic...
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