Article
A Recombinant Turkey Herpesvirus Expressing the F Protein of Newcastle Disease Virus Genotype XII Generated by NHEJ-CRISPR/Cas9 and Cre-LoxP Systems Confers Protection against Genotype XII Challenge in Chickens.
Viruses - 11 Apr 2022
Calderón Katherine, Rojas-Neyra Aldo, Carbajal-Lévano Brigith, Luján-Valenzuela Luis, Ticona Julio, Isasi-Rivas Gisela, Montalvan Angela, Criollo-Orozco Manuel, Huaccachi-Gonzáles Edison, Tataje-Lavanda Luis, Alvarez Karla Lucia F, Fernández-Sánchez Manolo, Fernández-Díaz Manolo, Tang Na, Yao Yongxiu, Nair Venugopal
Abstract excerpt
In this study, we developed a new recombinant virus rHVT-F using a Turkey herpesvirus (HVT) vector, expressing the fusion (F) protein of the genotype XII Newcastle disease virus (NDV) circulating in Peru. We evaluated the viral shedding and efficacy against the NDV genotype XII challenge in specific pathogen-free (SPF) chickens. The F protein expression cassette was inserted in the unique long (UL) UL45-UL46...
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