Article
An alternative CYB5A transcript is expressed in aneuploid ALL and enriched in relapse.
BMC genomic data - 18 Apr 2022
Bartsch Lorenz, Schroeder Michael P, Hänzelmann Sonja, Bastian Lorenz, Lázaro-Navarro Juan, Schlee Cornelia, Tanchez Jutta Ortiz, Schulze Veronika, Isaakidis Konstandina, Rieger Michael A, Gökbuget Nicola, Eckert Cornelia, Serve Hubert, Horstmann Martin, Schrappe Martin, Brüggemann Monika, Baldus Claudia D, Neumann Martin
Abstract excerpt
BACKGROUND: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a genetically heterogenous malignancy with poor prognosis in relapsed adult patients. The genetic basis for relapse in aneuploid subtypes such as near haploid (NH) and high hyperdiploid (HeH) BCP-ALL is only poorly understood. Pathogenic genetic alterations remain to be identified. To this end, we investigated the dynamics of genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.