Models for discovery of targeted therapy in genetic epileptic encephalopathies.

Abstract excerpt

Epileptic encephalopathies are severe disorders emerging in the first days to years of life that commonly include refractory seizures, various types of movement disorders, and different levels of developmental delay. In recent years, many de novo occurring variants have been identified in individuals with these devastating disorders. To unravel disease mechanisms, the functional impact of detected variants...

Topics

• Animals
• Antibodies, Monoclonal
• Anticonvulsants
• Brain Diseases
• Cell- and Tissue-Based Therapy
• Disease Models, Animal
• Drug Delivery Systems
• Epilepsy
• Excitatory Amino Acid Antagonists
• Genetic Predisposition to Disease