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Trophoblast antigens, fetal blood cell antigens, and the paradox of fetomaternal tolerance

19 Mar 2022

Abstract excerpt

The paradox of fetomaternal tolerance has puzzled immunologists and reproductive biologists alike for almost 70 yr. Even the idea that the conceptus evokes a uniformly tolerogenic immune response in the mother is contradicted by the long-appreciated ability of pregnant women to mount robust antibody responses to paternal HLA molecules and RBC alloantigens such as Rh(D). Synthesizing these older observations with...

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PMID: 35416936
DOI: 10.1084/jem.20211515

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