Article
Direct comparison of RT-ddPCR and targeted amplicon sequencing for SARS-CoV-2 mutation monitoring in wastewater.
The Science of the total environment - 10 Aug 2022
Lou Esther G, Sapoval Nicolae, McCall Camille, Bauhs Lauren, Carlson-Stadler Russell, Kalvapalle Prashant, Lai Yanlai, Palmer Kyle, Penn Ryker, Rich Whitney, Wolken Madeline, Brown Pamela, Ensor Katherine B, Hopkins Loren, Treangen Todd J, Stadler Lauren B
Abstract excerpt
Over the course of the COVID-19 pandemic, variants of SARS-CoV-2 have emerged that are more contagious and more likely to cause breakthrough infections. Targeted amplicon sequencing approach is a gold standard for identification and analysis of variants. However, when applied to environmental samples such as wastewater, it remains unclear how sensitive this method is for detecting variant-associated mutations in...
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