Key role of quorum‐sensing mutations in the development of Staphylococcus aureus clinical device‐associated infection

Abstract excerpt

In the present study, we show that the development of Staphylococcus aureus device-associated infection involves mutations in the quorum-sensing system Agr that increase biofilm formation and thereby bacterial resistance to antibiotics. The enormous difficulty clinicians face in the treatment of device-associated infections is due to the characteristic involvement of biofilms, which are bacterial agglomerations...

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