Article
Longitudinal study of 2 patients with cyclic thrombocytopenia, STAT3 and MPL mutations.
Blood advances - 10 Jan 2023
Zhang Haiyu, Chien May, Hou Yu, Shomali William, Brar Rondeep S, Ho Chandler, Han Panpan, Xu Danfei, Zhang Bing M, Guo Xiangqian, Tolentino Lorna L, Wu Nancy C, Tsai Albert G, Jin Jing, Witteles Wesley H, Chen Zhenping, Abidi Parveen, Jangam Diwash, Krieger Madison S, Craig Morgan, Bussel James B, Gotlib Jason R, Zehnder James L
Abstract excerpt
Cyclic thrombocytopenia (CTP) is a rare disease of periodic platelet count oscillations. The pathogenesis of CTP remains elusive. To study the underlying pathophysiology and genetic and cellular associations with CTP, we applied systems biology approaches to 2 patients with stable platelet cycling and reciprocal thrombopoietin (TPO) cycling at multiple time points through 2 cycles. Blood transcriptome analysis...
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