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Capture Sequencing Enables Sensitive Detection of Tick-Borne Agents in Human Blood

7 Mar 2022

Abstract excerpt

Assay sensitivity can be a limiting factor in the use of PCR as a tool for the detection of tick-borne pathogens in blood. We evaluated the performance of Tick-borne disease Capture Sequencing Assay (TBDCapSeq), a capture sequencing assay targeting tick-borne agents, to test 158 whole blood specimens obtained from the Lyme Disease Biobank. These included samples from 98 individuals with signs and symptoms of...

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PMID: 35330765
DOI: 10.3389/fmicb.2022.837621

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