Article
Whole genome capture of vector-borne pathogens from mixed DNA samples: a case study of Borrelia burgdorferi.
BMC genomics - 6 Jun 2015
Carpi Giovanna, Walter Katharine S, Bent Stephen J, Hoen Anne Gatewood, Diuk-Wasser Maria, Caccone Adalgisa
Abstract excerpt
BACKGROUND: Rapid and accurate retrieval of whole genome sequences of human pathogens from disease vectors or animal reservoirs will enable fine-resolution studies of pathogen epidemiological and evolutionary dynamics. However, next generation sequencing technologies have not yet been fully harnessed for the study of vector-borne and zoonotic pathogens, due to the difficulty of obtaining high-quality pathogen...
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