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Article

pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases.

Angewandte Chemie (International ed. in English) - 28 Sept 2015

Mena-Barragán Teresa, Narita Aya, Matias Dino, Tiscornia Gustavo, Nanba Eiji, Ohno Kousaku, Suzuki Yoshiyuki, Higaki Katsumi, Garcia Fernández José Manuel, Ortiz Mellet Carmen

Abstract excerpt

A general approach is reported for the design of small-molecule competitive inhibitors of lysosomal glycosidases programmed to 1) promote correct folding of mutant enzymes at the endoplasmic reticulum, 2) facilitate trafficking, and 3) undergo dissociation and self-inactivation at the lysosome. The strategy is based on the incorporation of an orthoester segment into iminosugar conjugates to switch the nature of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26386364
DOI: 10.1002/anie.201505147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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