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Article

UPF1 contributes to the maintenance of endometrial cancer stem cell phenotype by stabilizing LINC00963.

Cell death & disease - 22 Mar 2022

Chen Hao, Ma Jian, Kong Fanfei, Song Ning, Wang Cuicui, Ma Xiaoxin

Abstract excerpt

Endometrial cancer stem cells (ECSCs) play a vital role in endometrial cancer (EC) metastasis, relapse, and chemoresistance. However, the molecular mechanisms that sustain ECSCs remain elusive. Here, we showed that the expression of UPF1 was upregulated in EC tissues and ECSCs and correlated with poor clinicopathological characteristics. UPF1 silencing suppressed ECSC hallmarks, such as sphere formation ability,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35318304
DOI: 10.1038/s41419-022-04707-x
PMCID: PMC8940903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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