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A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines

16 Mar 2022

Abstract excerpt

Besides the isolation and identification of major histocompatibility complex I-restricted peptides from the surface of cancer cells, one of the challenges is eliciting an effective antitumor CD8+ T-cell-mediated response as part of therapeutic cancer vaccine. Therefore, the establishment of a solid pipeline for the downstream selection of clinically relevant peptides and the subsequent creation of therapeutic...

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PMID: 35314027
DOI: 10.7554/elife.71156

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