Role of the antigen presentation process in the immunization mechanism of the genetic vaccines against COVID‐19 and the need for biodistribution evaluations

Abstract excerpt

The mechanism of ‘traditional’ vaccines consists in inoculating viruses, which have been previously inactivated (e.g. by thermal treatments), or attenuated (e.g. by multiple passages in suboptimal growth conditions).1 Such viruses, which lost the ability to cause acute infection, allow the immune system to recognize them as exogenous pathogens, promoting the production of specific antibodies and memory-T...

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